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A study proposed that if alkali-injured eyes irrigated with H2 solution of 0.5–0.6 ppm for 30 min. The concentration of H2 effectively suppressed oxidative stress in the cornea and reduced corneal neovascularization. The injured eyes were irrigated with H2 solution (H2 in PBS) or PBS free of H2 immediately after the injury and then repeatedly for five days. Results showed that after H2 treatment corneal transparency that was lost after the injury quickly renewed and central corneal thickness that increased after the injury reached physiological levels. On day 20 after the injury in H2 treated corneas the intracorneal inflammation was suppressed, the retrocorneal membrane was not developed, and corneal neovascularization was reduced. This was in contrast to PBS treated alkali-injured corneas, where the intracorneal inflammation was highly developed together with the retrocorneal membrane, and corneas were largely vascularized.
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