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Molecular hydrogen has anti-oxidative, anti-apoptotic, and anti-inflammatory effects. Molecular hydrogen can readily permeate through biomembranes such as the blood-brain barrier, blood-testis barrier, and placental barrier, thus benefiting hard-to-reach organs (e.g., brain) and organelles due to its low molecular mass, non-ionic state, and hydrophobic properties. Molecular hydrogen offers important neuroprotective benefits in depression, anxiety, neuropathic pain, Parkinson’s disease, cognitive impairment, and brain injury via attenuating excessive inflammatory response and oxidative stress. Hydrogen-rich water exerts antidepressant-like effects by preventing oxidative stress, inflammation, and apoptosis in the prefrontal cortex and hippocampus.
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